![]() ![]() It is on the World Health Organization's List of Essential Medicines. įluoxetine was discovered by Eli Lilly and Company in 1972, and entered medical use in 1986. ![]() It has been suggested that fluoxetine therapy may be continued during breastfeeding if it was used during pregnancy or if other antidepressants were ineffective. Fluoxetine taken during pregnancy is associated with significant increase in congenital heart defects in the newborns. Antidepressant discontinuation syndrome is less likely to occur with fluoxetine than with other antidepressants, but it still happens in many cases. ![]() Serious side effects include serotonin syndrome, mania, seizures, an increased risk of suicidal behavior in people under 25 years old, and an increased risk of bleeding. Ĭommon side effects include indigestion, trouble sleeping, sexual dysfunction, loss of appetite, dry mouth, and rash. It has also been used to treat premature ejaculation. It is also approved for treatment of major depressive disorder in adolescents and children 8 years of age and over. It is used for the treatment of major depressive disorder, obsessive–compulsive disorder (OCD), bulimia nervosa, panic disorder, and premenstrual dysphoric disorder. Fluoxetine, sold under the brand names Prozac and Sarafem, among others, is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.
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